Discovery of artemisinin-glycolipid hybrids as anti-oral cancer agents.
نویسندگان
چکیده
Novel artemisinin-glycolipid hybrids were directly synthesized from 12β (C-C)-type deoxoartemisinin and glycolipid and exhibited exceptional in vitro anticancer activity, particularly against the oral carcinoma cancer cell lines, respectively. The artemisinin-glycolipid hybrids, with effective concentrations under 20 µM, demonstrated better anticancer activity than either artemisinin or glycolipid alone and showed five times more anti-oral cancer activity than either cisplatin or paclitaxel.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 59 12 شماره
صفحات -
تاریخ انتشار 2011